Carcinogenesis in the Uterine Cervix and Human Papillomavirus Infection

摘要: In 1842 an Italian physician, Rigoni-Stem, published a paper on the statistical evaluation of death records from cancer in city Verona for years 1760–1839. this remarkable document it was pointed out that deaths due to “cancer uterus” were rare among virgins and nuns quite common married women widows. Since is known other sources cervix by far most form uterine 19th century, may safely be assumed Rigoni-Stem first epidemiologist point “marital” or “sexual” events played important role development disease.