Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury

摘要: In this study we examined the induction of heme oxygenase-1 (HO-1) in glia traumatized rat brain. HO-1 was immunolocalized fixed sections brain 3 h to 5 days after injury. Induction enzyme astrocytes, microglia/macrophages, and oligodendrocytes evaluated using immunofluorescent double labeling with monoclonal antibodies glial fibrillary acidic protein, complement C3bi receptor, myelin basic protein. apparent injured hemisphere cerebellum as early 24 postinjury. The protein likewise noted similar regions at 72 postinjury but appeared be more widespread its distribution. At postinjury, there a notable decline degree immunostaining for HO-1. typically induced astrocytes cerebral cortex site impact, deep cortical layers adjacent hemorrhagic lesions, hippocampus. Bergmann vermis cerebellum. addition, also microglia/macrophages scattered throughout ipsilateral cortex, subarachnoid space. These findings demonstrate prolonged Such response may reflect protective role these cells against secondary insults including oxidative stress.