Microwave ablation energy delivery: influence of power pulsing on ablation results in an ex vivo and in vivo liver model.

摘要: Purpose: The purpose of this study was to compare the impact continuous and pulsed energy deliveries on microwave ablation growth shape in unperfused perfused liver models. Methods: A total 15 kJ at 2.45 GHz applied ex vivo bovine using one five delivery methods (n = 50 total, 10 per group): 25 W for min (25 average), 5 (50 100 2.5 (100 average). 30 porcine livers 35, 7 group) similar study, but with twice time offset heat loss blood perfusion. Temperatures were monitored 5–20 mm from antenna, values over 60 °C indicating acute cellular necrosis. Comparisons size made between experimental groups based delivery, average power applied, peak ANOVA post-hoc pairwise tests. Results: No significant differences noted sizes or circularities tissue. Temperature data demonstrated more rapid heating ablations, suggesting that pulsing may overcome perfusion coagulate tissues rapidly vivo. Differences despite equivalent among all groups. Overall, largest volume produced (265.7 ± 208.1 cm3). At average, pulsed-power volumes larger than continuous-power ablations (67.4 34.5 cm3 versus 23.6 26.5 cm3, P 0.43). Similarly, significantly greater length (P ≤ 0.01), increase diameter 0.09) a slight decrease circularity 0.97). When comparing groups, moderate ≥ 0.06) again slightly circular. Conclusions: Pulsed created zones low compared presence Shorter duty cycles appear provide benefit when pulsing.