Potency, Efficacy, and Antigenic Mapping of H7 Avian Influenza Virus Vaccines Against the 2012 H7N3 Highly Pathogenic Avian Influenza Virus from Mexico

摘要: In the spring of 2012 an outbreak H7N3 highly pathogenic (HP) avian influenza virus (AIV) occurred in poultry Mexico. Vaccination was implemented as a control measure, along with increased biosecurity and surveillance. At that time there no commercially available H7 AIV vaccine North America; therefore, recent wild bird isolate low pathogenicity from Mexico (A/cinnamon teal/Mexico/2817/2006 H7N3) selected utilized seed strain. these studies, potency efficacy this strain evaluated chickens against challenge Jalisco HPAIV. Although doses 256 102 hemagglutinating units (HAU) per decreased morbidity mortality significantly compared to sham vaccinates, dose 512 HAU required prevent completely. Additionally, 11 other vaccines antigenic map hemagglutination inhibition assay data all viruses were evaluated, both identify potential strains characterize relationship between genetic distance protection Several isolates provided adequate lineage, but differences not clear indicators because immunogenicity also critical factor.