Induction of string rescues the neuroblast proliferation defect in trol mutant animals.
作者： Youngji Park , Cristina Ng , Sumana Datta
DOI: 10.1002/GENE.10216
关键词:
摘要: Summary: In trol mutants, neuroblasts fail to exit G1 for S phase. Increasing string expression in mutants rescues the number of phase without an increase M neuroblasts. Decreasing further decreased Coexpression cyclin E and did not produce additional cells. Unlike E, cdk2, cdk2AF, elevated neither A, D, nor cdk1AF was able promote progression arrested neuroblasts, indicating that String-induced activity a Cyclin A or D complex is unlikely drive into Biochemical analyses revealed rapid E-Cdk2 kinase wild-type levels upon increased expression. These results suggest Drosophila Cdc25 may directly indirectly complexes vivo, thus driving cell division. genesis 36:187–195, 2003. © 2003 Wiley-Liss, Inc.
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