An active efflux system for heavy metals in cisplatin-resistant human KB carcinoma cells.
作者： Zhe-Sheng Chen , Masato Mutoh , Tomoyuki Sumizawa , Tatsuhiko Furukawa , Misako Haraguchi
关键词:
摘要: Abstract The mechanism for cisplatin resistance in cisplatin-resistant KCP-4 cells was studied. Although multidrug resistance-associated protein (MRP) not detected cells, the were more resistant to heavy metals than multidrug-resistant C-A120 that overexpressed MRP. expressed metallothionein, but it scarcely involved these cells. did express canalicular multispecific organic anion transporter (cMOAT). glutathione(GSH) level 4.7-fold higher KB-3-1 When GSH decreased by treating with buthionine sulfoximine and nitrofurantoin, accumulation of sensitivity cispaltin increased. only 3.0-fold this affected increased glutathione level. platinum 68.5 20.4% respectively, while intracellular levels antimony potassium tartrate 13.2 9.9% respectively. ATP-dependent efflux enhanced both These results, taken together, suggest an pump different from MRP cMOAT is
elsevier.com
sci-hub.se 参考文章(39)
Patrick J Loehrer, LAWRENCE H EINHORN, Cisplatin Annals of Internal Medicine. ,vol. 100, pp. 704- 713 ,(1984) , 10.7326/0003-4819-100-5-704
I Leier, G Jedlitschky, U Buchholz, S P Cole, R G Deeley, D Keppler, The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. Journal of Biological Chemistry. ,vol. 269, pp. 27807- 27810 ,(1994) , 10.1016/S0021-9258(18)46856-1
T Ishikawa, F Ali-Osman, Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells : molecular characterization of glutathione-platinum complex and its biological significance Journal of Biological Chemistry. ,vol. 268, pp. 20116- 20125 ,(1993) , 10.1016/S0021-9258(20)80702-9
Stephen B. Howell, Dennis D. Heath, Peter Naredi, Robert E. Enns, Cross-Resistance between Cisplatin and Antimony in a Human Ovarian Carcinoma Cell Line Cancer Research. ,vol. 54, pp. 6464- 6468 ,(1994)
Gary D. Kruh, Toru Miki, Andrew Chan, Stuart A. Aaronson, Kim Myers, Kathleen Gaughan, Expression Complementary DNA Library Transfer Establishes mrp as a Multidrug Resistance Gene Cancer Research. ,vol. 54, pp. 1649- 1652 ,(1994)
Kurt C. Almquist, David R. Hipfner, Roger G. Deeley, Susan P. C. Cole, Caroline E. Grant, Gunnar Valdimarsson, Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Research. ,vol. 54, pp. 357- 361 ,(1994)
Kazuhiro Kagotani, Shin-ichi Akiyama, Morimasa Wada, Michihiko Kuwano, Ken Taniguchi, Takeshi Kawabe, Kimitoshi Kohno, Mina Kawakami, Katsuzumi Okumura, Takanori Nakamura, A Human Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene Is Overexpressed in Cisplatin-resistant Human Cancer Cell Lines with Decreased Drug Accumulation Cancer Research. ,vol. 56, pp. 4124- 4129 ,(1996)
Nandigama Krishnamachary, The MRP Gene Associated with a Non-P-glycoprotein Multidrug Resistance Encodes a 190-kDa Membrane Bound Glycoprotein Cancer Research. ,vol. 53, pp. 3658- 3661 ,(1993)
Victoria M. Richon, Alan Eastman, Nancy Schulte, Multiple Mechanisms of Resistance to cis-Diamminedichloroplatinum(II) in Murine Leukemia L1210 Cells Cancer Research. ,vol. 47, pp. 2056- 2061 ,(1987)
SY Loh, P Mistry, LR Kelland, G Abel, KR Harrap, Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: circumvention studies using novel platinum (II) and (IV) ammine/amine complexes. British Journal of Cancer. ,vol. 66, pp. 1109- 1115 ,(1992) , 10.1038/BJC.1992.419