Circuit topology for synchronizing neurons in spontaneously active networks

摘要: Spike synchronization underlies information processing and storage in the brain. But how can neurons synchronize a noisy network? By exploiting high-speed (500–2,000 fps) multineuron imaging technique large-scale synapse mapping method, we directly compared spontaneous activity patterns anatomical connectivity hippocampal CA3 networks ex vivo. As to unconnected pairs, synaptically coupled shared more common presynaptic neurons, received correlated excitatory synaptic inputs, emitted synchronized spikes with approximately 107 times higher probability. Importantly, parents per se than unshared upstream neurons. Consistent this, dynamic-clamp stimulation revealed that inputs alone could not account for realistic degree of unless among parents. On macroscopic scale, network was coordinated by power-law scaling synchronization, which engaged varying sets densely interwired (thus highly synchronized) neuron groups. Thus, locally coherent converges on specific cell assemblies, thereby yielding complex ensemble dynamics. These segmentally pulse packets may serve as modules flow associatively parallel channels.