Abnormal Accumulation of Luteal Bodies in Ovaries of the Senescence Accelerated Mouse (SAM)

摘要: The senescence accelerated mouse prone (SAMP) mice with a shortened life span show changes in many of the signs aging and have shorter reproductive than SAM resistant (SAMR) controls. SAMP is more that SAMR. In present study, we found abnormal accumulation luteal bodies (LBs) only ovaries and, examined mechanism abnormalities cell regression mice. No significant were detected serum progesterone or 17β-estradiol levels during estrus cycle between SAMR abnormally accumulated LBs mice, extremely high activity 20α-hydroxysteroid dehydrogenase, which catalyzes conversion to inactive form, 20α-hydroxyprogesterone demonstrated histochemically. However, no marked differences 17β-hydroxysteroid dehydrogenase Moreover, apoptotic cells Extremely weak immunohistochemical reactivity for endothelial nitric oxide synthase (eNOS) was noted but seen inducible NOS (iNOS). expression eNOS- iNOS-mRNA eNOS-mRNA at stage metestrus stages may be useful model examine mammalian ovaries.