PIK3CA in cancer: The past 30 years.

作者: Rand Arafeh , Yardena Samuels

DOI: 10.1016/J.SEMCANCER.2019.02.002

关键词:

摘要: … GDC-0077 is a new PI3Kα inhibitor that selectively degrades mutant PI3Kα in a proteasome-… the safety, tolerability, and pharmacokinetics of GDC-0077 administered as a single agent in …

参考文章(244)
F. Shibasaki, Y. Homma, T. Takenawa, TWO TYPES OF PHOSPHATIDYLINOSITOL 3-KINASE FROM BOVINE THYMUS : MONOMER AND HETERODIMER FORM Journal of Biological Chemistry. ,vol. 266, pp. 8108- 8114 ,(1991) , 10.1016/S0021-9258(18)92948-0
C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry. ,vol. 269, pp. 5241- 5248 ,(1994) , 10.1016/S0021-9258(17)37680-9
C L Carpenter, B C Duckworth, K R Auger, B Cohen, B S Schaffhausen, L C Cantley, Purification and characterization of phosphoinositide 3-kinase from rat liver. Journal of Biological Chemistry. ,vol. 265, pp. 19704- 19711 ,(1990) , 10.1016/S0021-9258(17)45429-9
H Yano, S Nakanishi, K Kimura, N Hanai, Y Saitoh, Y Fukui, Y Nonomura, Y Matsuda, Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. Journal of Biological Chemistry. ,vol. 268, pp. 25846- 25856 ,(1993) , 10.1016/S0021-9258(19)74466-4
Dan Robinson, Eliezer M Van Allen, Yi-Mi Wu, Nikolaus Schultz, Robert J Lonigro, Juan-Miguel Mosquera, Bruce Montgomery, Mary-Ellen Taplin, Colin C Pritchard, Gerhardt Attard, Himisha Beltran, Wassim Abida, Robert K Bradley, Jake Vinson, Xuhong Cao, Pankaj Vats, Lakshmi P Kunju, Maha Hussain, Felix Y Feng, Scott A Tomlins, Kathleen A Cooney, David C Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E Rathkopf, Michael J Morris, Stephen B Solomon, Jeremy C Durack, Victor E Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T Lis, Michaela Bowden, Stephen P Balk, Glenn Gaviola, Carrie Sougnez, Manaswi Gupta, Y Yu Evan, Elahe A Mostaghel, Heather H Cheng, Hyojeong Mulcahy, Lawrence D True, Stephen R Plymate, Heidi Dvinge, Roberta Ferraldeschi, Penny Flohr, Susana Miranda, Zafeiris Zafeiriou, Nina Tunariu, Joaquin Mateo, Raquel Perez-Lopez, Francesca Demichelis, Brian D Robinson, Marc Schiffman, David M Nanus, Scott T Tagawa, Alexandros Sigaras, Kenneth W Eng, Olivier Elemento, Andrea Sboner, Elisabeth I Heath, Howard I Scher, Kenneth J Pienta, Philip Kantoff, Johann S De Bono, Mark A Rubin, Peter S Nelson, Levi A Garraway, Charles L Sawyers, Arul M Chinnaiyan, None, Integrative clinical genomics of advanced prostate cancer Cell. ,vol. 161, pp. 1215- 1228 ,(2015) , 10.1016/J.CELL.2015.05.001
Jelena Kolic, Aliya F. Spigelman, Alannah M. Smith, Jocelyn E. Manning Fox, Patrick E. MacDonald, Insulin Secretion Induced by Glucose-dependent Insulinotropic Polypeptide Requires Phosphatidylinositol 3-Kinase γ in Rodent and Human β-Cells Journal of Biological Chemistry. ,vol. 289, pp. 32109- 32120 ,(2014) , 10.1074/JBC.M114.577510
Marta Duenas, Mónica Martínez‐Fernández, Ramón García‐Escudero, Felipe Villacampa, Miriam Marqués, Cristina Saiz‐Ladera, José Duarte, Victor Martínez, Mª José Gómez, Mª Luisa Martín, Manoli Fernández, Daniel Castellano, Francisco X Real, Jose L Rodriguez‐Peralto, Federico De La Rosa, Jesús M Paramio, None, PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors. Molecular Carcinogenesis. ,vol. 54, pp. 566- 576 ,(2015) , 10.1002/MC.22125
Pablo Rodriguez-Viciana, Patricia H. Warne, Ritu Dhand, Bart Vanhaesebroeck, Ivan Gout, Michael J. Fry, Michael D. Waterfield, Julian Downward, PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS Nature. ,vol. 370, pp. 527- 532 ,(1994) , 10.1038/370527A0
Peter K. Vogt, Jonathan R. Hart, Marco Gymnopoulos, Hao Jiang, Sohye Kang, Andreas G. Bader, Li Zhao, Adam Denley, Phosphatidylinositol 3-Kinase: The Oncoprotein Current Topics in Microbiology and Immunology. ,vol. 347, pp. 79- 104 ,(2010) , 10.1007/82_2010_80