The efficacy of 18F-FDG PET/CT and 67Ga SPECT/CT in diagnosing fever of unknown origin.

摘要: Abstract Objective Fever of unknown origin (FUO) is a diagnostic challenge. This study aimed to assess the efficacy fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) and gallium-67 single-photon computed 67 Ga SPECT/CT) in diagnosing FUO. Methods A total 68 patients with FUO underwent PET/CT SPECT/CT from January 2013 through May 2016. Images were read independently. The imaging results compared final diagnosis categorized as helpful for or non-contributory clinical setting. Associations between categorical variables evaluated chi-square test Fisher's exact test. Results Ten excluded. An infectious underlying disease was found 23 patients. malignant disorder cause 10 Non-infectious inflammatory 11 Adrenal insufficiency two not 12 high false-positive rate 44% (7/16) observed PET/CT, while false-negative 55% (23/42) SPECT/CT. studies depicted all Ga-avid lesions. sensitivity (79% vs. 45%) contribution (72% 55%) significantly higher than those p Conclusions On basis this study, performance superior work-up With its rapid sensitivity, may replace where technique available.