Crossed unilateral lesions of temporal lobe structures and cholinergic cell bodies impair visual conditional and object discrimination learning in monkeys.

摘要: Monkeys with excitotoxic lesions of the CA1/subiculum region in right hemisphere and immunotoxic cholinergic cells diagonal band left were impaired on a visual conditional task. In this task, correct choice one two objects depends which background fields both are presented against, irrespective spatial positions objects. They not simple object or shape discrimination tasks. The pattern impairments is same as that seen after bilateral CA1/subiculum, implying lesion disables ipsilateral CA1/subiculum. It also argues sustained by its input, necessary for some forms nonspatial learning. Addition an inferotemporal (IT) cortical ablation to did affect learning, although all monkeys then failed learn new This demonstrates intact IT cortex only sufficient sustain learning but implies input hippocampus contribute subsequent addition basal nucleus Meynert resulted additional impairment difficult discrimination. it projection cortex, rather than rest contributes memory.