Glucocorticoid binding proteins in myeloblasts of acute myelogenous leukemia
作者： Marc E. Lippman , Seymour Perry , E.Brad Thompson
DOI: 10.1016/0002-9343(75)90357-5
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摘要: The myeloblasts of 16 patients with untreated acute myelogenous leukemia were examined for specific glucocorticoid binding proteins. In only 3 the such high affinity receptors found. presence protein activity was positively correlated inhibition macromolecular synthesis in vitro whereas absence associated lack cells. Since glucocorticoids appear efficacious a small fraction cases leukemia, determination may provide assistance planning chemotherapeutic regimens.
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