Immunohistochemical Localization of Aspergillus and p53 in Human Lung Tissues

摘要: Aspergilli are filamentous fungi which can cause opportunistic infections in Acquired Immunodeficiency Syndrome (AIDS) patients. be found human tissues either the form of spores or hyphae. p53 is a tumor suppressor gene located short arm of chromosome 17. It is a potent transcriptional regulator genes involved many cellular activities including cell cycle arrest, apoptosis and angiogenesis. A loss function the most common event leading to development cancers. The rate by has a homology between different species been reported from other vertebrates, it has been that available within Drosophila melanogaster C. elegans [1] [2]. aim of this study check if localized not using immunohistochemical techniques and relationship infection lung tissues. 45 different samples tissues, diagnosed as being none tumor, were taken randomly during the year 2003-2004 autopsy cases submitted forensic medicine center Irbid, Jordan. The sample group consisted 12 females 33 males. Labeled Streptavidin Biotin (LSAB) method Mach-4 method used determine p53. results show Aspergillus presented all (100% infection) hyphae infected have mutant molecules (p53 was Aspergillus spores hyphae). According this study, safe posit molecules may for its multiplication. Seemingly biological behavior Aspergillus to produce fate questioned, going interact with cells initiating cancer? Further experimental investigations required such pathway. In conclusion, shows producing agent pathogenicity is caused production