Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells

摘要: SPECIFIC AIMVascular endothelial growth factor (VEGF) has multiple cytokine functions in cells that are carried out through intracellular signaling pathways whereas the other cell-specific ligand, angiopoietin-1 (Ang1), varied affects on VEGF activity cells. This study seeks to determine role of Ang1 VEGF- and tumor necrosis α (TNF-α) -induced expression tissue primary cultured reveal pathway which fulfills this role.PRINCIPAL FINDINGS1. inhibits TNF-α-induced TF expressionWe examined effect human umbilical vein (HUVECs). (200 ng/ml) by itself did not produce any significant mRNA level HUVECs for up 12 h (Fig. 1⤻ , Fig. 2⤻ ,;F1,2> anddata shown). However, at 1 2 h, respectively, inhibited ∼65% 62% VEGF-induced ∼...