Cell-mediated immune responses to poliovirus. I. Conditions for induction, characterization of effector cells, and cross-reactivity between serotypes for delayed hypersensitivity and T cell proliferative responses.
作者： Kegiang Wang , Lizhe Sun , Burk Jubelt , Carl Waltenbaugh
DOI: 10.1016/0008-8749(89)90242-6
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摘要: Abstract Human polioviruses are categorized into three distinct serotypes (types 1, 2, and 3) based upon their reactivity with specific antibodies. Although a great deal of information has been amassed about the induction characterization poliovirus antibody responses, little is known cell-mediated immunity to its role in protection. Here, we show that intracutaneous injection ultraviolet light-inactivated tailbase BALB/c mice induces delayed hypersensitivity (DTH) T-cell proliferative (Tprlf) responses. Both DTH Tprlf responses mediated by Ly-1 high2−, L3T4-bearing T cells. Moreover, serologic cross-reactivity (i.e., antibody-mediated) not predictive between immune
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