Gene recombinant bone marrow mesenchymal stem cells as a tumor-targeted suicide gene delivery vehicle in pulmonary metastasis therapy using non-viral transfection
作者： Tian-Yuan Zhang , Bing Huang , Zhong-Yue Yuan , Yu-Lan Hu , Yasuhiko Tabata
DOI: 10.1016/J.NANO.2013.06.003
关键词:
摘要: One of the main limitations anti-tumor gene therapy is lack an effective way to deliver therapeutic genes tumor sites. Bone marrow mesenchymal stem cells (BMSCs) have been proposed as cellular delivery vehicles sites in tumor-targeted cancer therapy. Here, we investigated effects cytomegalovirus-thymidine kinase expressing BMSCs (TK-BMSCs) on pulmonary melanoma metastasis combined with prodrug ganciclovir. were successfully engineered through a non-viral vector. The recombinant migrated area and found tendency target nodules after systemic delivery. In vitro results demonstrate that significant suicide presence ganciclovir dose-dependent manner can exert sufficient bystander effect B16F10 co-culture experiments. vivo studies confirmed TK-BMSCs/ganciclovir model.
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