S100A4 participates in epithelial-mesenchymal transition in breast cancer via targeting MMP2

摘要: Numerous studies have shown that S100A4 acquires its metastasis-promoting effects via inducing epithelial-mesenchymal transition (EMT). However, role and mechanism in EMT breast cancer had not been clearly elucidated. Herein, we showed the knockdown of expression cell lines, MDA-MB-231 MDA-MB-468, inhibited only invasion ability greatly, but also occurrence significantly. In addition, could decrease MMP2, a promoter mediator processes cancer. Above all, restoring MMP2 MDA-MB-468 rescue by S100A4, reverse suppressed S100A4. summary, our results indicated promote cells EMT, more importantly, it participate regulating Therefore, be candidate biomarker for defining metastasis useful target therapy.