p19INK4D and cell death.
作者： Luz E. Tavera-Mendoza , Tian-Tian Wang , John H. White
DOI: 10.4161/CC.5.6.2585
关键词:
摘要: INK4 proteins are members of a family cyclin-dependent kinase (CDK) inhibitors that function in G1 to block the activity CDKs 4 and 6. While they share clear structural similarities, numerous studies have shown differ their expression patterns during development adult, differing roles tumor suppression. A recent study from our laboratory showed gene encoding p19INK4D is induced by hormonal form vitamin D3 retinoids, both which signal through related nuclear receptor transcription factors. Although retinoids distinct developmental physiological functions, regulate cell cycle been chemopreventive effects range studies. Induction contributed arrest ligands. However, knockdown rendered cells sensitive autophagic death, remarkable phenotype given hyperproliferative responses loss ot...
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