Vascular Endothelial Growth Factor A and Proliferation Marker in Prediction of Lymph Node Metastasis in Oral and Pharyngeal Squamous Cell Carcinoma

摘要: Objective To explore the effect of Ki-67 and vascular endothelial growth factor A (VEGF-A) expression on risks advanced T category (T3,4) positive lymph node involvement (N+) in oral pharyngeal squamous cell carcinoma (SCC) compared with laryngeal SCC. Design Immunohistochemical analysis prospectively recruited patients. Setting University-affiliated hospital. Patients total 147 previously untreated patients different stages SCC cavity, pharynx, larynx. Main Outcome Measures Relative T3,4 tumor N+, a risk ratio comparing under high vs low marker expression. Results significant association VEGF-A was observed for ( P  ≤ .006). Regarding nodal status, N+ all tumors  ≤ .009), whereas related to only  = .009), additional raised value 6.12 (2.09-17.93; Conclusions Proliferative status common this series. Exploitation metastasis addition proliferation by but not explains clinical aggressiveness SCC, especially early lymphatic invasion. In management cervical nodes, combined may help identify at occult metastases. This study suggests anti–VEGF-A therapy, an intervention classic antiproliferative regimen, preventing progression