Timing and spacing of ubiquitin-dependent DNA damage bypass

摘要: During its duplication, DNA, the carrier of our genetic information, is particularly vulnerable to decay, and capacity cells deal with replication stress has been recognised as a major factor protecting us from genome instability cancer. One pathways controlling bypass DNA lesions during activated by ubiquitylation sliding clamp, PCNA. Whereas monoubiquitylation PCNA allows mutagenic translesion synthesis damage-tolerant polymerases, polyubiquitylation required mainly for an error-free pathway that likely involves template switching. This review focussed on understanding timing damage cell cycle question how it coordinated progression forks.