EML4-ALK: honing in on a new target in non-small-cell lung cancer.
作者： Leora Horn , William Pao
关键词:
摘要: … Importantly, lung cancers that harbor genomic ALK alterations may be clinically responsive to pharmacologic ALK inhibition. Just as treatment of lung cancer cells bearing drug-sensitive …
sci-hub.se 参考文章(35)
Sven Perner, Patrick L Wagner, Francesca Demichelis, Rohit Mehra, Christopher J LaFargue, Benjamin J Moss, Stefanie Arbogast, Alex Soltermann, Walter Weder, Thomas J Giordano, David G Beer, David S Rickman, Arul M Chinnaiyan, Holger Moch, Mark A Rubin, EML4-ALK Fusion Lung Cancer: A Rare Acquired Event Neoplasia. ,vol. 10, pp. 298- 302 ,(2008) , 10.1593/NEO.07878
Gregory J. Riely, Mark G. Kris, Daniel Rosenbaum, Jenifer Marks, Allan Li, Dhananjay A. Chitale, Khedoudja Nafa, Elyn R. Riedel, Meier Hsu, William Pao, Vincent A. Miller, Marc Ladanyi, Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clinical Cancer Research. ,vol. 14, pp. 5731- 5734 ,(2008) , 10.1158/1078-0432.CCR-08-0646
Carolyn D. Seib, Flavio G. Rocha, Dick G. Hwang, Brent T. Shoji, Gastrosplenic Fistula From Hodgkin's Lymphoma Journal of Clinical Oncology. ,vol. 27, ,(2009) , 10.1200/JCO.2008.21.7695
A. V. Galkin, J. S. Melnick, S. Kim, T. L. Hood, N. Li, L. Li, G. Xia, R. Steensma, G. Chopiuk, J. Jiang, Y. Wan, P. Ding, Y. Liu, F. Sun, P. G. Schultz, N. S. Gray, M. Warmuth, Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 270- 275 ,(2007) , 10.1073/PNAS.0609412103
Isabelle Janoueix-Lerosey, Delphine Lequin, Laurence Brugières, Agnès Ribeiro, Loïc de Pontual, Valérie Combaret, Virginie Raynal, Alain Puisieux, Gudrun Schleiermacher, Gaëlle Pierron, Dominique Valteau-Couanet, Thierry Frebourg, Jean Michon, Stanislas Lyonnet, Jeanne Amiel, Olivier Delattre, Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma Nature. ,vol. 455, pp. 967- 970 ,(2008) , 10.1038/NATURE07398
Kentaro Inamura, Kengo Takeuchi, Yuki Togashi, Satoko Hatano, Hironori Ninomiya, Noriko Motoi, Ming-yon Mun, Yukinori Sakao, Sakae Okumura, Ken Nakagawa, Manabu Soda, Young Lim Choi, Hiroyuki Mano, Yuichi Ishikawa, EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Modern Pathology. ,vol. 22, pp. 508- 515 ,(2009) , 10.1038/MODPATHOL.2009.2
Young Lim Choi, Kengo Takeuchi, Manabu Soda, Kentaro Inamura, Yuki Togashi, Satoko Hatano, Munehiro Enomoto, Toru Hamada, Hidenori Haruta, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Toshihide Ueno, Shuji Takada, Yoshihiro Yamashita, Yukihiko Sugiyama, Yuichi Ishikawa, Hiroyuki Mano, Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer Cancer Research. ,vol. 68, pp. 4971- 4976 ,(2008) , 10.1158/0008-5472.CAN-07-6158
Daisy Wing-Sze Wong, Elaine Lai-Han Leung, Kimpton Kam-Ting So, Issan Yee-San Tam, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, Kwok-Keung Ho, Joseph Siu-Kie Au, Lap-Ping Chung, Maria Pik Wong, , The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. ,vol. 115, pp. 1723- 1733 ,(2009) , 10.1002/CNCR.24181
Yuyan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Lili Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara, Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa, Oncogenic mutations of ALK kinase in neuroblastoma. Nature. ,vol. 455, pp. 971- 974 ,(2008) , 10.1038/NATURE07399
S. Morris, M. Kirstein, M. Valentine, K. Dittmer, D. Shapiro, D. Saltman, A. Look, Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma Science. ,vol. 263, pp. 1281- 1284 ,(1994) , 10.1126/SCIENCE.8122112