Determinants of the ability of malignant fibroma virus to induce immune dysfunction and tumor dissemination in vivo.
作者： David S. Strayer , Katherine A. Laybourn , Hillary K. Heard
DOI: 10.1016/0882-4010(90)90020-Q
关键词:
摘要: The relationship of virus-induced immunological dysfunction and tumor dissemination was studied using two related tumor-causing leporipoxviruses: malignant fibroma virus (MV) Shope (SFV). Recombinant viruses, produced by transferring MV's 10.7 kb BamHI C fragment to SFV, replicate in lymphocytes suppress lymphocyte function vitro. Those recombinants that vitro share about 3.5 from fragment. Some mimic MV producing immune suppression disseminated infection vivo. Other recombinants, even some are highly immunosuppressive (e.g. R71), only variably induce vivo, do not cause disease. A segment DNA transfers almost all virulence vivo identified.
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