Immunologic dysfunction during viral oncogenesis

摘要: Abstract The ability of two related viruses—Shope fibroma virus (SFV) and malignant rabbit (MV)—to induce virus-specific immune responses in lymphocytes recipient animals was studied. SFV produces a benign local tumor which regresses 12–14 days. Using an assay for virus-induced lymphocyte blastogenesis reactive to were detected, both rabbits bearing SFV-induced tumors whose had regressed. These virus-reactive cells detected peripheral blood spleen, lymph nodes draining the primary tumor. In contrast, MV disseminated eventual death. does not detectable blastogenic populations. are antigenically cross reactive: do develop MV-induced tumors, antisera each neutralize equally. Lymphocytes from SFV-infected proliferate vitro response that has been inactivated by ultraviolet light (uv/MV) but infectious MV. infected with respond uv-inactivated or SFV. Thus, inhibits development normal vivo prevents expression those MV-resistant, SFV-immune . relevance this impairment differences clinical courses SFV- is discussed.