Cytotoxic and antiplasmodial compounds from the roots of Strophioblachia fimbricalyx.

摘要: The known phenanthrenone trigonostemone (1), along with a new phenanthrenone, 9-O-demethyltrigonostemone (2), and two phenanthropolones, 3,6,9-trimethoxyphenanthropolone (3) 4,6,9-trimethoxyphenanthropolone (4), were isolated from the roots of Strophioblachia fimbricalyx. Compound 2 showed cytotoxicity against NCI-H187, KB, MCF7 cancer cells IC50 values 0.8, 2.9 microg/mL, respectively, while 3 4 reduced cytotoxicity. Compounds displayed antiplasmodial activity in vitro (IC50 2.7 3.2 respectively) Plasmodium falciparum (K1, resistant strain). In addition, antioxidant 1-4 toward DPPH radicals was determined, but only compound any discernible activity.