Concise review: custodians of the transcriptome: how microRNAs guard stemness in squamous epithelia.

摘要: At the core of every dynamic epithelium resides a population carefully regulated stem cells ensuring its maintenance and balance. The complex mammalian epidermis is no exception to this rule. last decade has delivered wealth knowledge regarding biology adult cells, but questions still remain intricate details their function maintenance. To help address these gaps, we turn small, single-stranded RNA molecules known as microRNAs. Since discovery, microRNAs have provided us with novel insights ground-breaking impulses enhance our understanding biological sciences. Due unique role in posttranscriptional regulation, are essential cutaneous well epidermal cell. By serving buffers balance between epithelial stemness, proliferation, differentiation, play roles transition out cell compartment. Following an updated overview microRNA biology, summarize current focusing on three major players that dominated recent literature: miR-205, miR-203, miR-125b. We then review clinical applications, discussing potential therapeutic targets regenerative oncological cell-based medicine.