Geldanamycin administration reduces the amount of primordial germ cells in the mouse embryo.
作者： M. Lejong , M. Choa-Duterre , N. Vanmuylder , S. Louryan
DOI: 10.1016/J.MORPHO.2018.05.001
关键词:
摘要: Summary Introduction Heat shock proteins (HSPs) are expressed or overexpressed in response to exposure stress. They act as molecular chaperones, ensuring the correct folding of numerous client proteins. HSP90 is one most conserved HSPs. Its role extends beyond stress tolerance. also contributes development, differenciation, apoptosis and oncogenesis. Numerous tumors associated with an overexpression this expression can be used evaluate its metastatic capacity. Primordial germ cells (PGCs) exhibit under normal conditions. PGCs arise early development migrate by a combination passive active movements towards gonads. The aim work was study impact inhibition on migration PGCs. Geldanamycin, well established inhibitor potent antitumor properties achieve inhibition. Materiel methods 5 mg Geldanamycin were administered E8 pregnant mice. E17 embryos removed fixed for staining Immunohistochemistry anti-HSP90 anti-VASA antibodies. Results Geldanamycin-treated mouse exhibited less VASA-immunopositive compared non-treated ones. These results suggest that geldanamycin administration at time reduces number VASA stainings identical. We therefore idea could reliable marker
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sci-hub.se 参考文章(21)
Nathalie Vanmuylder, M Choa-Duterre, Marcel Rooze, Stéphane Louryan, Patrick Salvia, Hassina Larbi, L'administration de geldanamycine réduit le nombre de gonocytes exprimant l'HSP86 chez l'embryon de souris: premiers résultats. Revue Médicale de Bruxelles. ,vol. 30, pp. 23- 27 ,(2009)
Nathalie Vanmuylder, Marcel Rooze, Marie-Alexandra Lambot, Stéphane Louryan, HSP 86: un rôle dans l’évolution humaine ? Anthropologica et praehistorica. ,vol. 114, pp. 19- 23 ,(2003)
Johannes Buchner, Jing Li, Structure, Function and Regulation of the Hsp90 Machinery Biomedical Journal. ,vol. 36, pp. 106- ,(2013) , 10.4103/2319-4170.113230
Nathalie Vanmuylder, Aimée Werry-Huet, Marcel Rooze, Stéphane Louryan, Heat shock protein HSP86 expression during mouse embryo development, especially in the germ-line. Anatomy and Embryology. ,vol. 205, pp. 301- 306 ,(2002) , 10.1007/S00429-002-0258-5
Tomoyo Takeuchi, Yoko Tanigawa, Ryohei Minamide, Kohji Ikenishi, Tohru Komiya, Analysis of SDF-1/CXCR4 signaling in primordial germ cell migration and survival or differentiation in Xenopus laevis Mechanisms of Development. ,vol. 127, pp. 146- 158 ,(2010) , 10.1016/J.MOD.2009.09.005
Komal Jhaveri, Tony Taldone, Shanu Modi, Gabriela Chiosis, Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. ,vol. 1823, pp. 742- 755 ,(2012) , 10.1016/J.BBAMCR.2011.10.008
Paul Lasko, The DEAD-box helicase Vasa: Evidence for a multiplicity of functions in RNA processes and developmental biology Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. ,vol. 1829, pp. 810- 816 ,(2013) , 10.1016/J.BBAGRM.2013.04.005
Jürg Stebler, Derek Spieler, Krasimir Slanchev, Kathleen A. Molyneaux, Ulrike Richter, Vlad Cojocaru, Victor Tarabykin, Chris Wylie, Michael Kessel, Erez Raz, Primordial germ cell migration in the chick and mouse embryo: the role of the chemokine SDF-1/CXCL12 Developmental Biology. ,vol. 272, pp. 351- 361 ,(2004) , 10.1016/J.YDBIO.2004.05.009
Aftab Taiyab, Ch. Mohan Rao, HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion Biochimica et Biophysica Acta. ,vol. 1813, pp. 213- 221 ,(2011) , 10.1016/J.BBAMCR.2010.09.012
J.A. Fernández, E.J. Bubner, Y. Takeuchi, G. Yoshizaki, T. Wang, S.F. Cummins, A. Elizur, Primordial germ cell migration in the yellowtail kingfish (Seriola lalandi) and identification of stromal cell-derived factor 1 General and Comparative Endocrinology. ,vol. 213, pp. 16- 23 ,(2015) , 10.1016/J.YGCEN.2015.02.007