Fibroblast Growth Factors Are Required for Efficient Tumor Angiogenesis

摘要: Although the function of vascular endothelial growth factor in induction tumor angiogenesis is well understood, role a second group angiogenic factors, fibroblast factors (FGFs), remains elusive. We used recombinant adenovirus expressing soluble FGF receptor (AdsFGFR) to interfere with angiogenesis. AdsFGFR repressed cell proliferation vitro and inhibited an ex vivo bioassay, which cells were cocultured biopsies collagen gel. Moreover, hence allograft transplantation experiments. Whereas adenoviral expression form VEGF 1 (AdsFlt) predominantly affected initiation angiogenesis, (sFGFR) appeared impair maintenance The combination sFGFR Flt exhibited synergistic effect repression growth. Finally, i.v. injection resulted dramatic transgenic mouse model pancreatic β carcinogenesis. Similar control infections AdsFlt, tumor-associated vessel density was decreased, indicating that impaired These data indicate FGFs play critical