作者: Benjamin D. Pope , Curtis R. Warren , Kevin Kit Parker , Chad A. Cowan
DOI: 10.1016/J.TCB.2016.05.005
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摘要: The properties of tissue-specific microenvironments vary widely in the human body and demonstrably influence structure function many cell types. Adipocytes are no exception, responding to cues specialized niches perform vital metabolic endocrine functions. adipose microenvironment is remodeled during tissue expansion maintain structural functional integrity disrupted remodeling obesity contributes progression syndrome, breast cancer, other malignancies. increasing incidence these obesity-related diseases recent focus on improved vitro models biology underscore growing interest regulatory role adipocyte health disease.