Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
作者： David Cortez , Yi Wang , Jun Qin , Stephen J Elledge
DOI: 10.1126/SCIENCE.286.5442.1162
关键词:
摘要: The Brca1 (breast cancer gene 1) tumor suppressor protein is phosphorylated in response to DNA damage. Results from this study indicate that the checkpoint kinase ATM (mutated ataxia telangiectasia) was required for phosphorylation of ionizing radiation. resides a complex with and vivo vitro region contains clusters serine-glutamine residues. Phosphorylation domain appears be functionally important because mutated lacking two sites failed rescue radiation hypersensitivity Brca1-deficient cell line. Thus, by may critical proper responses double-strand breaks provide molecular explanation role breast cancer.
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