Histone acetylation influences the activity of Sox9-related transcriptional complex.
作者： Takayuki Furumatsu , Hiroshi Asahara
DOI: 10.18926/AMO/41320
关键词:
摘要: Chondrocyte differentiation is the fundamental process in skeletal development. From mesenchymal condensation of chondroprogenitors to hypertrophic maturation chondrocytes, chondrogenesis sequentially regulated by cross-talk among transcription factors, growth and chromatin structure. The master factor Sry-type HMG box (Sox) 9 has an essential role expression chondrogenic genes through association with Sox9-binding sites on its target genes. Several factors coactivators, such as Scleraxis/E47 p300, cooperatively modulate Sox9-dependent interacting Sox9. Sox9-related transcriptional apparatus activates gene p300-mediated histone acetylation chromatin. transforming (TGF)-β superfamily also plays a key chondrocyte differentiation. TGF-β-regulated Smad3/4 complex associating Sox9 itself, recruiting p300 onto These findings suggest that epigenetic status including modification structure, directly influences Sox9-regulated In this article, we review regulators modulators posttranslational function, Sox9-associating regulation during chondrogenesis.
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