Meninges: A Widespread Niche of Neural Progenitors for the Brain.

摘要: Emerging evidence highlights the several roles that meninges play in relevant brain functions as they are a protective membrane for brain, produce and release trophic factors important neural cell migration survival, control cerebrospinal fluid dynamics, embrace numerous immune interactions affecting parenchymal functions. Furthermore, different groups have identified subsets of progenitors residing during development adulthood mammalian species, including humans. Interestingly, these immature cells able to migrate from parenchyma differentiate into functional cortical neurons or oligodendrocytes. Immature promptly react disease. Injury-induced expansion meningeal been observed following experimental demyelination, traumatic spinal cord injury, amygdala lesion, stroke, progressive ataxia. In this review, we summarize data on function stem niche presence meninges, discuss their health consider potential exploitation regenerative medicine treat neurological disorders.