Meninges harbor cells expressing neural precursor markers during development and adulthood

摘要: Brain and skull developments are tightly synchronized, allowing the cranial bones to dynamically adapt brain shape. At brain-skull interface, meninges produce trophic signals necessary for normal corticogenesis bone development. Meninges harbor different cell populations, including cells forming endosteum of vault. Recently, we other groups have described presence in a population endowed with neural differentiation potential vitro and, after transplantation, vivo. However, whether may be niche progenitor during embryonic development adulthood remains determined. In this work provide first description distribution precursor markers rat up adulthood. We conclude that share common properties classical stem niche, as they: i) highly proliferating tissue; ii) host expressing such nestin, vimentin, Sox2 doublecortin; iii) enriched extracellular matrix components (e.g. fractones) known bind concentrate growth factors. This study underlines importance endogenous