Gene therapy for brain tumors

摘要: Gene therapy has opened new doors for treatment of neoplastic diseases. This approach seems very attractive, especially glioblastomas, since these brain tumors failed using conventional regimens. Many different modes gene have been tested in culture and vivo. approaches are based on previously established anti-neoplastic principles, like prodrug activating enzymes, inhibition tumor neovascularization, enhancement the normally weak anti-tumor immune response. Delivery genes to cells mediated by a number viral synthetic vectors. The most widely used paradigm is activation ganciclovir cytotoxic compound enzyme, thymidine kinase, which expressed cells, after introduced retroviral vector. proven be potent with minimal side effects several rodent models, proceeded phase 1 clinical trials. In this review, current strategies vector systems will described discussed light further developments needed make modality clinically efficacious.