Prior alcohol consumption and mortality following acute myocardial infarction

摘要: ContextStudies have found that individuals who consume 1 alcoholic drink every 1 to 2 days a lower risk of first acute myocardial infarction (AMI) than abstainers or heavy drinkers, but the effect prior drinking on mortality after AMI is uncertain.ObjectiveTo determine alcohol consumption long-term mortality among early survivors AMI.Design and SettingProspective inception cohort study conducted at 45 US community and tertiary care hospitals between August 1989 September 1994, with median follow-up 3.8 years.PatientsA total 1913 adults hospitalized 1994.Main Outcome MeasureAll-cause mortality, compared by self-reported average weekly consumption of beer, wine, liquor during year AMI.ResultsOf patients, 896 (47%) abstained from alcohol, 696 (36%) consumed less than 7 drinks/wk, 321 (17%) consumed more alcoholic drinks/wk. Compared abstainers, patients less drinks/wk had all-cause mortality rate (3.4 vs 6.3 deaths per 100 person-years; hazard ratio [HR], 0.55; 95% confidence interval [CI], 0.43-0.71) as did those who drinks/wk (2.4 person-years; HR, 0.38; CI, 0.25-0.55; P<.001 for trend). After adjusting propensity other potential confounders, increasing alcohol remained predictive 7 drinks/wk, an adjusted HR 0.79 (95% 0.60-1.03), more drinks/wk, 0.68 0.45-1.05; P = .01 trend). The association was similar cardiovascular mortality, among both men women, different types alcoholic beverages.ConclusionSelf-reported moderate in AMI is associated reduced following infarction.