Stereoselective formation of a 2′(3′)-aminoacyl ester of a nucleotide
作者： Arthur L. Weber
DOI: 10.1007/BF02100034
关键词:
摘要: Reaction of DL-serine and adenosine-5-phosphorimidazolide in the presence adenosine-5'-(O-methylphosphate) imidazole resulted stereoselective synthesis aminoacyl nucleotide ester 2'(3')-O-seryl-adenosine-5'-(O-methylphosphate). The enantiomeric excess D-serine incorporated into 2'(3')-O-seryl-adenosine-5'-(O-methylphosphate) was about 9%. Adenylyl-(5'----N)-serine an unknown product also D-serine; however, serylserine showed L-serine. relationship these results to origin biological pairing L-amino acids nucleotides containing D-ribose is discussed.
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