A Phase II Study of AT-101 to Overcome Bcl-2–Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer
作者： Mark N. Stein , Maha Hussain , Walter M. Stadler , Glenn Liu , Irina V. Tereshchenko
DOI: 10.1016/J.CLGC.2015.09.010
关键词:
摘要: Background We conducted a phase II study in men with castration-sensitive metastatic prostate cancer to test the hypothesis that AT-101, a small molecule Bcl-2 inhibitor, has clinical activity in patients initiating androgen deprivation therapy (ADT) for metastatic prostate cancer. Materials and Methods Patients with metastatic prostate cancer scheduled to start, or who had recently (within 6 weeks) initiated, ADT were enrolled. ADT with a luteinizing hormone-releasing hormone agonist and bicalutamide was started 6 weeks …
elsevier.com
sci-hub.se 参考文章(19)
Guoping Wang, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Renxiao Wang, Guozhi Tang, Jie Guo, Sanjeev Shangary, Su Qiu, Wei Gao, Dajun Yang, Jennifer Meagher, Jeanne Stuckey, Krzysztof Krajewski, Sheng Jiang, Peter P. Roller, Hatice Ozel Abaan, York Tomita, Shaomeng Wang, Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. Journal of Medicinal Chemistry. ,vol. 49, pp. 6139- 6142 ,(2006) , 10.1021/JM060460O
Robert D. Loberg, Natalie McGregor, Chi Ying, Erin Sargent, Kenneth J. Pienta, In Vivo Evaluation of AT-101 (R-(-)-Gossypol Acetic Acid) in Androgen-Independent Growth of VCaP Prostate Cancer Cells in Combination with Surgical Castration Neoplasia. ,vol. 9, pp. 1030- 1037 ,(2007) , 10.1593/NEO.07778
Natalie McGregor, Lalit Patel, Matthew Craig, Savannah Weidner, Shaomeng Wang, Kenneth J. Pienta, AT-101 ( R -(−)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model Journal of Cellular Biochemistry. ,vol. 110, pp. 1187- 1194 ,(2010) , 10.1002/JCB.22633
Mario A. Eisenberger, Brent A. Blumenstein, E. David Crawford, Gary Miller, David G. McLeod, Patrick J. Loehrer, George Wilding, Kathy Sears, Daniel J. Culkin, Ian M. Thompson, Anton J. Bueschen, Bruce A. Lowe, Bilateral orchiectomy with or without flutamide for metastatic prostate cancer The New England Journal of Medicine. ,vol. 339, pp. 1036- 1042 ,(1998) , 10.1056/NEJM199810083391504
Sylvan C. Baca, Davide Prandi, Michael S. Lawrence, Juan Miguel Mosquera, Alessandro Romanel, Yotam Drier, Kyung Park, Naoki Kitabayashi, Theresa Y. MacDonald, Mahmoud Ghandi, Eliezer Van Allen, Gregory V. Kryukov, Andrea Sboner, Jean-Philippe Theurillat, T. David Soong, Elizabeth Nickerson, Daniel Auclair, Ashutosh Tewari, Himisha Beltran, Robert C. Onofrio, Gunther Boysen, Candace Guiducci, Christopher E. Barbieri, Kristian Cibulskis, Andrey Sivachenko, Scott L. Carter, Gordon Saksena, Douglas Voet, Alex H. Ramos, Wendy Winckler, Michelle Cipicchio, Kristin Ardlie, Philip W. Kantoff, Michael F. Berger, Stacey B. Gabriel, Todd R. Golub, Matthew Meyerson, Eric S. Lander, Olivier Elemento, Gad Getz, Francesca Demichelis, Mark A. Rubin, Levi A. Garraway, Punctuated Evolution of Prostate Cancer Genomes Cell. ,vol. 153, pp. 666- 677 ,(2013) , 10.1016/J.CELL.2013.03.021
S. Doyle-Lindrud, S. Beers, S. Goodin, Eric Rubin, Robert S. DiPaola, A. Thalasila, Elizabeth Poplin, J. Shih, Dmitri Dvorzhinski, T. Capanna, A phase I trial of weekly paclitaxel, 13- cis-retinoic acid, and interferon alpha in patients with prostate cancer and other advanced malignancies. Cancer Chemotherapy and Pharmacology. ,vol. 52, pp. 119- 124 ,(2003) , 10.1007/S00280-003-0644-6
Michael J. Morris, Carlos Cordon-Cardo, William K. Kelly, Susan F. Slovin, Karen Siedlecki, Kevin P. Regan, Robert S. DiPaola, Mohamed Rafi, Neal Rosen, Howard I. Scher, Safety and biologic activity of intravenous BCL-2 antisense oligonucleotide (G3139) and taxane chemotherapy in patients with advanced cancer. Applied Immunohistochemistry & Molecular Morphology. ,vol. 13, pp. 6- 13 ,(2005) , 10.1097/00129039-200503000-00002
William R. Schelman, Tabraiz A. Mohammed, Anne M. Traynor, Jill M. Kolesar, Rebecca M. Marnocha, Jens Eickhoff, Michael Keppen, Dona B. Alberti, George Wilding, Naoko Takebe, Glenn Liu, A phase i study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer Investigational New Drugs. ,vol. 32, pp. 295- 302 ,(2014) , 10.1007/S10637-013-9999-7
Timothy J. McDonnel, Nora M. Navone, Patricia Troncoso, Louis L. Pisters, Claudio Conti, Andrew C. von Eschenbach, Shawn Brisbay, Christopher J. Logothetis, Expression of BCL-2 Oncoprotein and P53 Protein Accumulation in Bone Marrow Metastases of Androgen Independent Prostate Cancer The Journal of Urology. ,vol. 157, pp. 569- 574 ,(1997) , 10.1016/S0022-5347(01)65204-2
G. Sonpavde, V. Matveev, J.M. Burke, J.R. Caton, M.T. Fleming, T.E. Hutson, M.D. Galsky, W.R. Berry, P. Karlov, J.T. Holmlund, B.A. Wood, M. Brookes, L. Leopold, Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer Annals of Oncology. ,vol. 23, pp. 1803- 1808 ,(2012) , 10.1093/ANNONC/MDR555