Epidermal growth factor receptor in colorectal carcinoma: correlation with clinico-pathological prognostic factors.
作者： H. S. Abd El All , A. M. Mishriky , F. A. Mohamed
DOI: 10.1111/J.1463-1318.2007.01306.X
关键词:
摘要: Objective This study was undertaken to determine the relationship between epidermal growth factor receptor (EGFR) status in primary colorectal cancer (CRC) different clinico-pathological prognostic factors. Method Seventy-nine CRC were studied using four scoring systems: 1- EGFR pharmDx score, 2- score modified from Hercept test [J Histo cytochem, 52 (2004) 893], 3- two additive scores with cutoff points [Mod Pathol, 11 (1998) 155], 4- multiplicative [Ann Oncol, 16 (2005) 102]. Results More than 10% membranous reactivity identified 46.8% (37/79) of tumours. The intensity classified as mild, moderate and strong representing 8.9%, 20.3% 17.7% respectively. Strong correlation found proposed scores, at (P < 0.01). A expression, advanced clinical stage (P < 0.01), nodal involvement (P < 0.01) lympho-vascular invasion (LV) (P < 0.05) category I factors, poorly differentiated tumours IIA (P < 0.05), infiltrative border configuration IIB perineural (PN) III larger IV Heterogenous staining present 46.3% associated an increased LV PN (P < 0.05). Conclusion Using a cut-off point 10%, similar results systems obtained, standardization for interpretation. expression is correlated conventional factors.
sci-hub.se 参考文章(39)
A. Karameris, P. Kanavaros, D. Aninos, V. Gorgoulis, G. Mikou, Th. Rokas, M. Niotis, N. Kalogeropoulos, Expression of Epidermal Growth Factor (EGF) and Epidermal Growth Factor Receptor (EGFR) in Gastric and Colorectal Carcinomas1 Pathology Research and Practice. ,vol. 189, pp. 133- 137 ,(1993) , 10.1016/S0344-0338(11)80082-8
Frederick L. Greene, AJCC cancer staging handbook : from the AJCC cancer staging manual Springer. ,(2002)
G Carpenter, S Cohen, Epidermal growth factor. Journal of Biological Chemistry. ,vol. 265, pp. 7709- 7712 ,(1972) , 10.1016/S0021-9258(19)38983-5
Karin Koretz, Peter Schlag, Peter Möller, Expression of epidermal growth factor receptor in normal colorectal mucosa, adenoma, and carcinoma. Virchows Archiv. ,vol. 416, pp. 343- 349 ,(1990) , 10.1007/BF01605295
Sufi Mary Thomas, Jennifer Rubin Grandis, Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation. Cancer Treatment Reviews. ,vol. 30, pp. 255- 268 ,(2004) , 10.1016/J.CTRV.2003.10.003
Alexander A. Parikh, Fan Fan, Wen Biao Liu, Syed A. Ahmad, Oliver Stoeltzing, Niels Reinmuth, Diane Bielenberg, Corazon D. Bucana, Michael Klagsbrun, Lee M. Ellis, Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. American Journal of Pathology. ,vol. 164, pp. 2139- 2151 ,(2004) , 10.1016/S0002-9440(10)63772-8
HW Lo, MC Hung, None, Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival British Journal of Cancer. ,vol. 94, pp. 184- 188 ,(2006) , 10.1038/SJ.BJC.6602941
Andrew J. Wilson, Peter R. Gibson, Role of epidermal growth factor receptor in basal and stimulated colonic epithelial cell migration in vitro. Experimental Cell Research. ,vol. 250, pp. 187- 196 ,(1999) , 10.1006/EXCR.1999.4496
Alan W. Hemming, Noelle L. Davis, Andreas Kluftinger, Bruce Robinson, Noel F. Quenville, Babette Liseman, Jean Lcriche, Prognostic markers of colorectal cancer: an evaluation of DNA content, epidermal growth factor receptor, and Ki-67. Journal of Surgical Oncology. ,vol. 51, pp. 147- 152 ,(1992) , 10.1002/JSO.2930510304
Yimin Wang, Shinsei Minoshima, Nobuyoshi Shimizu, Precise mapping of the EGF receptor gene on the human chromosome 7p12 using an improved FISH technique Journal of Human Genetics. ,vol. 38, pp. 399- 406 ,(1993) , 10.1007/BF01907986