Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β

摘要: Tumor-associated macrophages (TAMs) are frequently found in glioblastomas and a high degree of macrophage infiltration is associated with poor prognosis for glioblastoma patients. However, it unclear whether TAMs promote tumor growth. In this study, we that folate receptor β (FRβ) was expressed on human rat C6 glioma implanted subcutaneously nude mice. To target FRβ-expressing TAMs, produced recombinant immunotoxin consisting immunoglobulin heavy light chain Fv portions an anti-mouse FRβ monoclonal antibody Pseudomonas exotoxin A. Injection the into xenografts mice significantly depleted reduced The targeting will provide therapeutic tool glioblastomas.