Cassane diterpenes from the seed kernels of Caesalpinia sappan
作者： Hai Xuan Nguyen , Nhan Trung Nguyen , Phu Hoang Dang , Phuoc Thi Ho , Mai Thanh Thi Nguyen
DOI: 10.1016/J.PHYTOCHEM.2015.12.018
关键词:
摘要: Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures determined by extensive NMR and CD spectroscopic analysis. Among compounds, tomocin A, phanginin F, H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.
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