Remodeling the clock: coactivators and signal transduction in the circadian clockworks.

摘要: Most organisms on earth such as cyanobacteria, fungi, plants, insects, animals, and humans synchronize their physiological behavioral activities with the environmental cycles of day night. Significant progress has been made in unraveling genetic components that constitute a molecular circadian clock, which facilitates temporal control physiology behavior. Clock genes assemble interlocked transcriptional/translational feedback loops underlie oscillations. Recent investigations revealed posttranslational regulation clock proteins is crucial for functioning oscillator precise transcription. This review provides an overview homologous clockworks Drosophila mammals, special focus recent insights well role coactivators, repressors, signal transduction controlled genome-wide The emerging mechanisms gene provide understanding transcription general orchestration behavior particular.