Immunohistochemical staining in the distinction between primary endometrial and endocervical adenocarcinomas: another viewpoint.

摘要: Several studies have reported on the use of antibodies to monoclonal carcinoembryonic antigen (CEA) and vimentin (VIM) distinguish between adenocarcinomas endometrial (EM) endocervical (EC) origin, with variably enthusiastic results. It is still unclear whether site origin or pathway differentiation (endometrioid [em] versus mucinous [m]) more important in predicting immunohistochemical differences. In present study, paraffin blocks from known were retrieved immunostained VIM CEA, as well cytokeratins (CK) 4, 18, 20, estrogen receptor (ER), progesterone (PR). Positivity was scored a scale 0 12, emphasis pattern (tumors mixed patterns received separate scores for em m foci). Mean CEA emEM (n = 27), mEM (17), mEC (10), emEC (6) 0.4, 0.9, 5.1, 1.2, respectively. 6.9, 1.3, 0, 4.4; ER, 5.7, 4.2, 1.6; PR, 7.6, 2.8, 0.1, 6.0; CK4, 9.2, 4.4, 8.5, 10.6; CK18, 6.4, 3.4, 5.5, 8.4; CK20, 0.7, 0.5, 0.4. Both influenced these results, latter former both (only frequently strongly positive), neither CKs studied. No one stain combination reliably distinguished origin. The only immunostaining that might identify accuracy than hematoxylin & eosin evaluation alone high ER an endometrioid carcinoma, suggesting about 95% this series tumor.