The immunohistochemical discrimination of endometrioid adenocarcinomas

摘要: Carcinomas of endometrioid histology frequently arise in the endometrium, ovary, and endocervix involve pelvic tissues women. Adenocarcinomas psuedoendometrioid morphology developing colon also ovary. The authors retrospectively examined 97 adenocarcinomas from uterus, cervix, to ascertain whether site origin could be determined by using a battery antibodies with immunoperoxidase method on formalin-fixed tissue. This study was restricted tumors morphology. There were 27 endometrial, 16 ovarian, 23 endocervical adenocarcinomas, 31 colonic adenocarcinomas. included vimentin (V), monoclonal carcinoembryonic antigen (mCEA), CEA D-14. V-positive cells defined presence crisp paranuclear band staining, CEA-positive showed irregular or diffuse cytoplasmic staining. V diffusely decorated 22 (81.4%) endometrial tumors, 3 (13%) (rare, focal staining), stained 5 (31.3%) ovarian rare 2 (6.4%) tumors. Both negative for staining both but 65.2% (CEA D-14) 95.6% (monoclonal CEA) 83.8% D14) 90.3% (mCEA) conclude that endometrium ovary are most often strongly positive negative, which greatly aids distinguishing them pseudoendometrioid arising colon, only rarely, very focally positive. do not allow discrimination between D-14 offered no immunodiagnostic superiority over mCEA. These results support use immunohistochemistry is assisting distinction primary sites curettage specimens metastatic sites.