Pulmonary Hypertension and Right Heart Dysfunction in Chronic Lung Disease

摘要: Group 3 pulmonary hypertension (PH) is a common complication of chronic lung disease (CLD), including obstructive (COPD), interstitial disease, and sleep-disordered breathing. Development PH associated with poor prognosis may progress to right heart failure, however, in the majority patients CLD, mild moderate only small number develop severe PH. The pathophysiology CLD multifactorial includes hypoxic vasoconstriction, vascular remodeling, vessel destruction, fibrosis. effects on ventricle (RV) range between early RV hypertrophy, dilatation, eventual failure increased mortality. golden standard for diagnosis catheterization, evidence can be appreciated clinical examination, serology, radiological imaging, Doppler echocardiography. Treatment focuses management underlying disorder hypoxia. There is, limited suggest that PH-specific vasodilators such as phosphodiesterase-type 5 inhibitors, endothelin receptor antagonists, prostanoids have role treatment moderate-to-severe