Erythrocyte Remodeling in Plasmodium berghei Infection: The Contribution of SEP Family Members

摘要: The malaria parasite Plasmodium largely modifies the infected erythrocyte through export of proteins to multiple sites within host cell. This remodeling is crucial for pathology and translocation virulence factors surface. In this study, we investigated localization small exported proteins/early transcribed membrane (SEP/ETRAMPs), conserved genus. protein family characterized by a predicted signal peptide, short lysine-rich stretch, an internal transmembrane domain highly charged C-terminal region variable length. We show here that members rodent berghei are components parasitophorous vacuole (PVM), which surrounds throughout erythrocytic cycle. During P. development, vesicle-like structures containing these detach from PVM en route cytosol. These SEP-containing vesicles remain associated with ghosts most probably anchored skeleton. Transgenic lines expressing green fluorescent appended different portions sep-coding allowed us define motifs required export. terminal appears be involved in protein-protein interactions.