Effect of Antihypertensive Drugs on the Renin-Angiotensin System

摘要: Renin release from the kidneys is controlled by four major mechanisms - renal baroreceptors, macula densa, sympathetic nervous system and other humoral ionic influences. Recently, importance of in modulating renin for a variety stimuli has become apparent. The adrenergic nerves act on specific beta-receptor to stimulate kidney. Those antihypertensive drugs that inhibit nerve transmission tend therefore lower plasma renin. beta-Adrenoreceptor blocking also generally inhibition both animals humans. Diuretics vasodilators contrast elevate levels. Plasma levels hypertensive patients are net result many diverse influences, similarly treated with level often opposing return towards normal after treatment patients. may offer guide more rational basis therapy future. However, primary aim patient should be his blood pressure, independent effect