Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.

摘要: Abstract We isolated a human gene (designated c-ros-1) homologous to the v-ros sequence of UR2 sarcoma virus. Ten exons, 1,414 base pairs spanning 26 kilobases, contained tyrosine kinase domain, transmembrane and part an extracellular domain carrying N glycosylation site which was not acquired by The predicted structure c-ros-1 is unique among src family clearly distinct from insulin receptor.