Tissue-specific expression of rat c-ros-1 gene and partial structural similarity of its predicted products with sev protein of Drosophila melanogaster.
作者： H Matsushime , M Shibuya
DOI: 10.1128/JVI.64.5.2117-2125.1990
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摘要: The expression and predicted products of rat c-ros-1 gene, the proto-oncogene v-ros in UR2 sarcoma virus, were characterized. gene was found to be expressed a tissue-specific manner, sizes its transcripts heterogeneous: 8.2 kilobases (kb) long lung kidney tissues, 6.9 kb heart tissue, 2.4 1.9 testis tissue. cDNAs isolated from tissues. product tissue receptor-type tyrosine kinase 2,317 amino acids (including very large extracellular domain approximately 1,800 acids) which showed partial but significant structural homology with sev Drosophila melanogaster. An alternatively sliced transcript encode protein external transmembrane domains not catalytic domain. essentially identical that except for shorter amino-terminal region 21-amino-acid insertion On basis these results, appears active lungs kidneys probably hearts rats. Images
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