Novel reduction-sensitive pullulan-based micelles with good hemocompatibility for efficient intracellular doxorubicin delivery
作者： Xianwu Wang , Jingyun Wang , Yongming Bao , Benhua Wang , Xiaohong Wang
DOI: 10.1039/C4RA12276C
关键词:
摘要: A novel intracellular reduction-sensitive delivery system of doxorubicin (DOX), based on pullulan–stearic acid (P-ss-SA) conjugates with disulfide bonds as bonds, was successfully developed. The could self-assemble into micelles in aqueous media and encapsulate DOX. properties blank DOX-loaded were studied detail. results showed that the mean size around 187.7 nm 194.4 nm, respectively. drug loading content encapsulation efficiency P-ss-SA 6.19% 65.53%, increased dramatically under reductive conditions. release conditions much faster than non-reductive confocal laser microscopy flow cytometry measurements indicated broke triggered fast vitro IC50 lower without reduction-sensitivity against HepG2 MCF-7 cells. negligible cytotoxicity, possessed excellent hemocompatibility causing undesirable hemolysis. These biocompatible can be used potential carrier systems for
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