Molecular farming on rescue of pharma industry for next generations.

摘要: Recombinant proteins expressed in plants have been emerged as a novel branch of the biopharmaceutical industry, offering practical and safety advantages over traditional approaches. Cultivable various platforms (i.e. open field, greenhouses or bioreactors), hold great potential to produce different types therapeutic with reduced risks contamination human animal pathogens. To maximize yield quality plant-made pharmaceuticals, crucial factors should be taken into account, including host plants, expression cassettes, subcellular localization, post-translational modifications, protein extraction purification methods. DNA technology genetic transformation methods also contributed parts substantial improvements. play their proper function stability, require multiple modifications such glycosylation. Intensive glycoengineering research has performed reduce immunogenicity recombinant produced plants. Important strategies developed minimize proteolysis effects enhance accumulation. With growing population new epidemic threats, need for medications will paramount so that pharmaceutical industry not alone answer medication demands upcoming generations. Here, we review several aspects plant molecular pharming outline some important challenges hamper these ambitious biotechnological developments.