Fabrication of porous PCL/elastin composite scaffolds for tissue engineering applications
作者： Nasim Annabi , Ali Fathi , Suzanne M. Mithieux , Anthony S. Weiss , Fariba Dehghani
DOI: 10.1016/J.SUPFLU.2011.06.010
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摘要: Abstract We present the development of a technique that enables fabrication three-dimensional (3D) porous poly(ɛ-caprolactone) (PCL)/elastin composites. High pressure CO 2 was used as foaming agent to create large pores in PCL matrix and impregnate elastin into 3D structure scaffold. The effects process variables such temperature, pressure, processing time, depressurization rate, salt concentration on characteristics scaffolds were determined. Scaffolds with average pore sizes 540 μm porosity 91% produced using at 65 bar, 70 °C, time 1 h, rate 15 bar/min, addition 30 wt% particles. PCL/elastin composites then prepared under different conditions: ambient vacuum, high . vacuum resulted formation nonhomogenous scaffolds. However, uniform formed when 37 °C 60 bar.
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